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ADVA Select


ADVA SELECT

Specifications

Product: ADVA SELECT

Category: Cell Therapy

 Compatibility: Works with separation beads larger than 150 nm

Operating Conditions: Designed for use at room temperature

 

ADVA Select: A Revolutionary Device for T-Cell Isolation

ADVA Select is an innovative device developed by ADVA Biotechnology to streamline and enhance the process of T-cell isolation from whole blood or peripheral blood mononuclear cells (PBMCs). This cutting-edge technology is designed as a preparatory step for seeding cells into the ADVA X3 bioreactor, ensuring optimized outcomes for cell expansion and therapy applications. By integrating advanced magnetic separation technology with a user-friendly design, ADVA Select delivers unparalleled performance in the field of cell therapy.

Features and Design

One of the key highlights of ADVA Select is its compatibility with commercially available sterile blood or culture bags, tubing, and connectors. This feature makes it adaptable and convenient for use in existing workflows, minimizing disruptions while maintaining sterility. The ADVA Select Magnet is engineered for precision and reliability, ensuring efficient T-cell isolation in both research and clinical settings. Additionally, ADVA Select works with any commercial magnetic beads larger than 150 nm in diameter and performs exceptionally well with Dynabeads™ commercial beads.

The ADVA Select device is connected to the ADVA X3 bioreactor via a USB cable and is fully controlled through the ADVA X3 interface and software, creating a seamless and integrated workflow for cell isolation and expansion.

The single-use kit provided with ADVA Select includes easy-to-use connectors that eliminate the need for tubing welding and reduce confusion during setup. These connectors are FDA-approved and specifically designed to be compatible with the ADVA X3 single-use kit, ensuring a secure and efficient workflow.

The single-use kit provided with ADVA Select includes easy-to-use connectors that eliminate the need for tubing welding and reduce confusion during setup. These connectors are FDA-approved and specifically designed to be compatible with the ADVA X3 single-use kit, ensuring a secure and efficient workflow.

Benefits of ADVA Select

ADVA Select offers several distinct advantages that set it apart from other isolation devices:

  1. Ideal for Magnetic Isolation in Closed Systems:
    • The device is specifically designed to perform magnetic isolation within closed, sterile systems such as blood bags. This minimizes the risk of contamination and preserves the integrity of the isolated cells.
  2. Scalable Volumes:
    • ADVA Select supports scalable processing volumes, ranging from 50 to 500 mL in static separations. This flexibility allows it to accommodate various protocols, particularly following T-cell expansion procedures, ensuring it meets the needs of different applications.
  3. Connectivity and Flexibility:
    • ADVA Select can be connected to any ADVA X3 bioreactor. After the selection process, it can be easily moved from one system to another, providing unmatched flexibility and adaptability in workflows. The easy-to-use connectors further enhance its simplicity and reliability.
  4. Enhanced Functionality:
    • ADVA Select features automatic shaking with adjustable speeds, a strong magnetic field, and programmable settings, making it customizable to fit customer needs and specific protocols. These features contribute to its overall ease of use and reliability in diverse applications.

Applications

ADVA Select is versatile and suitable for various applications in cell therapy and research. It can be utilized for both positive and negative isolation processes:

  1. Positive Isolation:
    • This application involves selecting and isolating target T cells based on specific surface markers. By using magnetic beads conjugated to antibodies targeting desired cell markers, ADVA Select ensures the efficient recovery of high-purity T cells essential for therapeutic applications.
  2. Negative Isolation:
    • In negative isolation, unwanted cells are removed, leaving behind the untouched T-cell population. This method is particularly useful for preserving cell functionality and viability, which are critical for downstream applications.

 

ADVA Select represents a significant advancement in T-cell isolation technology. Its compatibility with existing sterile systems, scalability, and versatility make it a valuable tool for researchers and clinicians working in cell therapy and immunotherapy. By providing a reliable and efficient solution for magnetic isolation, ADVA Select paves the way for improved outcomes in cell expansion and therapeutic applications. With its integration into the ADVA X3 bioreactor workflow, this device is set to revolutionize the field of advanced cell manufacturing.

 

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