Revolutionizing the ability to treat cancer
The is an innovative, robust, and flexible cGMP cell manufacturing platform. Enabled by the CAMP™ technology and utilizing a single-use “end to end” solution.
The delivers cell therapy manufacturing as close as possible to the bedside. Allowing optimized culture conditions with tight quality assurance, resulting in significant cost reduction, therefore, ensuring availability of advanced therapies to patients.
The platform contains several compartments:
Controlled Colling Chamber – Unique chamber that allows fresh media bags to be stored in the optimal condition through the process. The fresh media bags in the chamber are connected by tubes to the conditioning chamber and can be replaced easily as needed.
Waste Chamber – External chamber in which the waste bags are located. The bags are connected to the single-use kit and allow waste to be emptied continuously during the process.
Core Reaction Chamber - Core reaction chamber is equipped with pull out drawer for easy kit installation with click-on optical sensors and a preset position for simplicity. The chamber includes all of the needed pumps, valves, sensors, and connectors, temperature-controlled allowing optimal conditions for cell growth.
Operating System - A modern operating system that allows remote control and monitoring of the process. The system contains software that enables the programming and design of any predefined protocols, by the end-user. The system processes the data collected from the various sensors and operates pumps, alerts, and controls accordingly.
The CX900s kit is a flexible, user-friendly, compact, automated, and closed disposable kit. Optimized for the production and downstream of CAR-T, TCR, TIL’s, NK cells, exosomes, and viruses. The disposable kit contains two main compartments: the conditioning chamber and the proprietary Cone growth chamber which are both controlled and synchronized, resulting in a continuous process manufacturing including all necessary steps from seed to final formulation. The chambers are interconnected with tubes and sensors allowing a closed and controlled process handling.
The Conditioning Chamber - contains the fresh medium used by the cells for growth. In this chamber, all controlled parameters such as the pH, oxygen and glucose levels are monitored and controlled by external gas control, or the addition of fresh media to enable the cell′;s optimal growth conditions.
The Cone – The Growth chamber. A proprietary chamber that supports the continuously growing of cells from 20 million to 20 billion including activation, transduction, washing, and formulation. The chamber operates in 4 different modes. The first mode of action is a controlled static culture chamber similar to a T-flask for low cell numbers. The second mode is a fed-batch mode as the cells start to expand. Once the chamber is full, it will switch to recirculation of the media between the growth chamber and the conditioning chamber, in which the media become refresh. At high consumption rates when the cells are at very high density and nutrients such as glucose or lactate hit their limits the system will switch to full perfusion mode. Once the reaction reaches its end, the system can perfuse wash buffer, wash the cells, reduce the volume and harvest the final drug substance ready for final formulation eliminating the need for downstream processing.
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