Valuing life, granting advance therapies to patients.

Contact Info

3 Hadolev Ave. Bar-Lev High-Tech Park, Israel, 2015600
info@advabio.com
+972 77-880-4900

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CAMP® Technology

 
CAMP® Enabled Technology
Continuous Adaptive Multi‑Parameter
 
Autologous cell therapy manufacturing demands consistent, high‑quality cell outputs, yet traditional manual processes are labor‑intensive, static, and provide limited insight into real‑time cellular behavior. With only intermittent measurements and minimal in‑process control, these systems cannot adapt to donor variability, often compromising performance.
ADVA X3® Enables that
Powered by CAMP® (Continuous Adaptive Multi‑Parameter) Technology, ADVA X3® delivers a Smart, Simple, Flexible, and Cost‑effective approach to cell manufacturing, unlike any other automation platform.
End‑to‑End Automation
Real‑Time AI Sensing
Single Closed Chamber
No Centrifugation
The Platform
A Fully Integrated, Adaptive Cell Manufacturing Platform
The ADVA X3® enables a fully automated, end‑to‑end cell culture process within a single, closed chamber, from activation and transduction through high‑density expansion.
By combining real‑time metabolic sensing with advanced machine learning and AI, the system continuously learns each donor’s cellular behavior and dynamically adapts culture conditions to maximize cell quality and yield.
 
 
 
 
Real‑Time Control
14 critical parameters, continuously controlled
ADVA X3® monitors and controls them throughout the entire process, keeping conditions optimal from start to finish, with minimal operator involvement.

 

How It Works
One Chamber. Five Adaptive Stages.
A single, closed system carries each donor’s cells from seeding to harvest, adapting in real time at every step.
Adva Cone culture chamber operating in batch mode
01 Batch Mode
Early‑stage processing in the Cone
The proprietary Cone culture chamber is designed for early‑stage processing, including seeding, recovery, activation, and transduction.
✓Embedded sensors measure conditions directly at the cell level
✓Continuous control of pH, dissolved oxygen, and temperature
✓Programmable automation for media handling and cell washing
✓Closed, sterile connections for sampling and supplementation
Adva Cone shearless flow path and mode of action
02 Shearless Flow
Gentle growth, physiologically relevant
A proprietary structured membrane guides media in a bottom‑to‑top flow, creating a gentle, shear‑free diffusion environment. By replicating the body’s natural nutrient dynamics, it enables cells to grow under truly optimal, physiologically relevant conditions.
✓Structured membrane drives a uniform bottom‑to‑top flow
✓Gentle, shear‑free diffusion protects cell integrity
✓Mirrors the body’s natural nutrient dynamics
Continuous adaptive multi-parameter perfusion control scheme
03 Cell Expansion
Full growth potential, every donor
A dedicated Media Conditioning Chamber continuously optimizes culture conditions, enabling each donor’s cells to reach their full growth potential.
✓Live control of pH, dissolved oxygen, glucose, lactate, glutamine, glutamate, and temperature
✓Adaptive perfusion based on real‑time cellular consumption
✓Continuous media circulation for efficient nutrient utilization
Full periodical perfusion media change control scheme
04 Media Change
Automatic, uninterrupted replenishment
When nutrient levels fall outside optimal ranges, the system automatically transitions to Media Change Mode, without interrupting the culture.
✓Spent media is removed while fresh media is introduced
✓Continuous perfusion ensures uninterrupted optimal conditions
✓Fully programmable based on process requirements
05 Cell Wash & Harvest
Harvest in minutes, without centrifugation
At the final stage, cells are washed and prepared for harvest without centrifugation, preserving high viability while keeping the process fast and gentle.
✓Gentle, programmable washing tailored to cell type
✓Automated formulation and volume control
✓Fast, efficient harvest in minutes to preserve viability
 
 
Powered by CAMP®
Smarter Cell Manufacturing Starts Here
ADVA X3® combines automation, real‑time insight, and adaptive intelligence to deliver consistent, high‑quality results, while reducing complexity, labor, and cost.
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